Towards a fish oil-based omega-3 therapy for preventing bone loss during chronic methotrexate chemotherapy
University of South Australia
Channel 7 Children's Research Foundation
Professor Cory Xian
While chemotherapy of acute lymphoblastic leukaemia (the major childhood cancer) has a 75% cure rate, it can cause significant bone loss that lacks protective treatments. Recently in rats treated with methotrexate (the major childhood cancer drug), we observed bone protective effects of dietary fish oil supplementation. Here we will evaluate its efficacy during chronic chemotherapy and define minimal effective intake of omega-3 fatty acids. This work will potentially lead toa safe and cost-effective strategy for ensuring bone health and life quality for children during and after chemotherapy.