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Cellular and Molecular Mechanism of Bone Pain Associated With Childhood Chemotherapy

University of South Australia
Channel 7 Children's Research Foundation
Dr Fiona Zhou

Project Summary

Chemotherapy has a high success rate in treating childhood cancer; yet it causes significant bone pain in patients, and increase in burden. Currently, how chemo induces skeletal pain is unclear, and the available analgesics are non-specific, temporary, and can cause adverse effects. Recently we observed an increase in production of pain inducing neuronal growth factors in our chemotherapy rat model. Here, we propose to investigate the cells and molecules involved in chemo-induced bone pain. This study will be valuable for developing specific and safe strategies for managing chemo bone pain.

Dr Fiona Zhou (email)
School of Pharmacy and Medical Sciences
University of South Australia
Business: 8 830 22374