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The role of a Type I secretion system in Pseudomonas aeruginosa biofilm formation

The University of Adelaide
Channel 7 Children's Research Foundation
Miss Victoria Lewis

Project Summary

Pseudomonas (P.) aeruginosa is a clinically significant, opportunistic pathogen, which is also the major cause of morbidity and mortality for individuals with Cystic Fibrosis (CF). In CF individuals, P. aeruginosa colonization occurs in early childhood, such that by the age of 19, 75 - 80% of patients have irreversible lung infections. P. aeruginosa infections persist despite long - term antibiotic treatment via the formation of biofilms. In this project, we will characterise the role of a novel protein secretion system that has a crucial role in the formation of P. aeruginosa biofilms.